- Epinephrine and norepinephrine are both acceptable, evidence-based approaches to hemodynamic support in septic shock.
- Individual patient responsiveness to vasopressors is variable and unpredictable.
- Some patients respond better to epinephrine than norepinephrine.
- For patients who are not responding well to norepinephrine, it is reasonable to empirically trial a low dose of epinephrine (“epinephrine challenge”).
