Dual antiplatelet therapy (DAPT) improves outcomes in patients with high-risk TIA or minor ischemic stroke

In patients with minor ischemic stroke or high-risk TIA, those who received a combination of clopidogrel and aspirin had a lower risk of major ischemic events but a higher risk of major haemorrhage at 90 days than those who received aspirin alone. However, the relative reduction in recurrent stroke occurred almost entirely during the first week, whereas bleeding events (most of which were not intracranial) were distributed fairly evenly throughout 90-day follow-up. Thus, it appears that one can maximize benefit and minimize harm by confining DAPT to just a few weeks