Postpartum Haemorrhage (PPH)

Tranexamic Acid

TXA is a safe, inexpensive medication that prevents fibrin breakdown.  In traumatic bleeding, it conveys a significant mortality benefit with an impressive NNT for mortality between 7 and 67, depending on injury severity, without apparent serious safety issues.  This benefit is associated with early administration.  TXA should not be given more than three hours after […]

Tranexamic Acid in PPH – WOMAN Trial

Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] […]

Tranexamic Acid for Severe Trauma – CRASH-2 Trial

Tranexamic acid (1g given over 10 min (IVI) followed by 1g given over 8h (IVI)) can save 1 in 67 patients with severe trauma CRASH-2: A large multicenter randomised control trial of 20,211 patients (CRASH2) found: The most severely injured patients who received TXA had the highest reduction in mortality. Benefits were greatest for those […]