Lactate in Sepsis: Pearls & Pitfalls…

Despite the ongoing controversy regarding the optimal endpoints of early sepsis resuscitation and the source of hyperlactemia, lactate remains the best non-invasive marker of illness severity. Given the current data, a ≥ 10% lactate clearance at 6 hours is an appropriate marker to follow when resuscitating a septic patient. However, recent research by Puskarich et […]

Serum Lactate. A predictor of badness in your patient

Lactate production in septic shock is not due to anaerobic metabolism or low oxygen delivery.  It is largely driven by endogenous epinephrine stimulating aerobic glycolysis via beta-2 adrenergic receptors. Lactate may have a protective effect, serving as a metabolic fuel for the heart and brain under conditions of stress. Elevated lactate is useful to identify […]

Emergency Medicine Kenya Foundation

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