Drug Toxicity 101

Paracetamol There are various clinical presentations of acetaminophen overdose, including asymptomatic, vague nausea/vomiting, acute liver failure, and even coma. A thorough history, in combination with laboratory data, is crucial for diagnosis. Rule of 150s => Toxic dose is approximately 150mg/kg Treatment with NAC should be implemented if >150 mg/kg acetaminophen level at 4 hours of presentation The initial […]

IV Iron

Indication: Severe iron-deficiency anemia (Hb <9 g/dL) especially if there is ongoing bleeding Rate of bleeding too brisk for oral iron Time-sensitive pressures (eg, an urgent surgical procedure; observational studies of the use of IV iron preoperatively for patients with anemia have shown a reduced rate of red cell transfusion being required) Severe anemia of […]

Emergency Medicine Kenya Foundation

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