CRASH-3 Trial: Tranexamic Acid in Mild-Moderate Head Injury

CRASH-3 Trial examined the effect of tranexamic acid on head injury-related death in adults with TBI who were within 3 h of injury, had a Glasgow Coma Scale (GCS) score of 12 or lower or any intracranial bleeding on CT scan, and no majorextracranial bleeding. The results indicated a reduction in the risk of head […]

Tranexamic Acid in PPH – WOMAN Trial

Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] […]

Subarachnoid Hemorrhage

Never ignore a headache that’s ‘different’, ‘never felt before’, ‘worst’ or not subsiding with ‘usual’ medicines…get a non-contrast CT Head

Tranexamic Acid for Severe Trauma – CRASH-2 Trial

Tranexamic acid (1g given over 10 min (IVI) followed by 1g given over 8h (IVI)) can save 1 in 67 patients with severe trauma CRASH-2: A large multicenter randomised control trial of 20,211 patients (CRASH2) found: The most severely injured patients who received TXA had the highest reduction in mortality. Benefits were greatest for those […]

Emergency Medicine Kenya Foundation

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