Drug Toxicity 101

Paracetamol There are various clinical presentations of acetaminophen overdose, including asymptomatic, vague nausea/vomiting, acute liver failure, and even coma. A thorough history, in combination with laboratory data, is crucial for diagnosis. Rule of 150s => Toxic dose is approximately 150mg/kg Treatment with NAC should be implemented if >150 mg/kg acetaminophen level at 4 hours of presentation The initial […]