Anaphylaxis is a sudden, severe allergic reaction that may cause death. The single most effective treatment for an episode of anaphylaxis is administration of epinephrine. Epinephrine is a chemical that arrests the chain of reactions that causes the signs and symptoms of anaphylaxis.
The late phase response, as noted, refers to the recrudescence of symptoms after an apparent temporary resolution. Such patients are said to experience biphasic anaphylaxis. Biphasic anaphylaxis is recurrent anaphylaxis occurring 1 to 72 hours after resolution of an initial anaphylactic episode, though an outside limit of 78 hours has also been suggested. Estimates of […]
The first step, before monitors are attached or IVs are even attempted, is to administer epinephrine 0.5mg IM in the lateral thigh. IM epinephrine can be repeated every 3-4 minutes.
In Anaphylaxis, IM Adrenaline (lateral thigh) is preferred over subcutaneous injection because it leads to a more rapid rise in plasma concentration. Only use IV if the patient has circulatory collapse – this can be done peripherally for a short time period if necessary…