Blood gas measurements in DKA

  • Guidelines recommend checking an ABG or VBG in all patients with DKA.  This practice is not evidence-based and should be abandoned.
  • ABG or VBG provides little information about whether or not the patient has DKA (beyond what is already known from the serum chemistries).
  • Rather than pH, serum bicarbonate may be used to gauge the severity of acidosis.
  • There is no evidence that detecting or reacting to a very low pH is helpful.
  • Decisions about the level of ventilatory support that a patient needs can almost always be made on a clinical basis.  When in doubt, close attention to the patient with serial examination is often a sound approach.  Focus on the patient, not the blood gas.
  • VBG might be helpful in cases where it is unclear whether the patient requires intubation, or if there is a significant underlying respiratory disease (e.g. COPD or obesity hypoventilation syndrome).

 

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Sodium bicarbonate therapy in DKA…DO NO HARM!!!

Sodium bicarbonate therapy in DKA (or any other acidosis for that matter) is associated with risks that outweigh NO BENEFITS…DO NO HARM!!!

  • Neither a recent systematic review nor the largest single retrospective cohort of severe DKA support routine use of bicarbonate therapy in DKA
  • Bicarbonate is associated with risk of cerebral oedema and prolonged hospitalisation in paediatric DKA

 

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