- LFTs = ‘hepatocellular’ or ‘cholestatic’ arrangement based on the pattern of elevation.
- Hepatocellular pattern = transaminases > ALK
- ALT is generally considered to be more specific to liver damage
- Magnitude of aminotransferase elevation => guide initial diagnosis: mild (<5x), moderate (5-10x), or marked elevation (>10x)
- Mild = NAFLD, Drug Induced Liver Injury, Alcohol Induced Liver Injury
- Moderate = Alcoholic Hepatitis, Biliary Tract Disease
- Severe = Acute Viral Hepatitis, Ischemic Injury, Acetaminophen Toxicity
