Tranexamic Acid for Severe Trauma – CRASH-2 Trial

Tranexamic acid (1g given over 10 min (IVI) followed by 1g given over 8h (IVI)) can save 1 in 67 patients with severe trauma

CRASH-2: A large multicenter randomised control trial of 20,211 patients (CRASH2) found:

The most severely injured patients who received TXA had the highest reduction in mortality. Benefits were greatest for those treated within 3 hours of injury and subgroup analysis demonstrated that TXA was most effective in patients with shock (systolic blood pressure < 75 mmHg).