What are the cornerstones for bronchiolitis treatment? Supportive care! This means ensuring adequate hydration and oxygenation. A limited amount of suctioning to clear the nares might be beneficial. Supplemental oxygen may be necessary if oxygen saturations are < 90% persistently. Antipyretics (acetaminophen or ibuprofen) for infants with high fever are often useful adjuncts for treatment and can reduce irritability.